An intact Pms2 ATPase domain is not essential for male fertility
نویسندگان
چکیده
منابع مشابه
Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice
Sphingolipids and the derived gangliosides have critical functions in spermatogenesis, thus mutations in genes involved in sphingolipid biogenesis are often associated with male infertility. We have generated a transgenic mouse line carrying an insertion in the sphingomyelin synthase gene Sms1, the enzyme which generates sphingomyelin species in the Golgi apparatus. We describe the spermatogene...
متن کاملThe Rice AAA-ATPase OsFIGNL1 Is Essential for Male Meiosis
Meiosis is crucial in reproduction of plants and ensuring genetic diversity. Although several genes involved in homologous recombination and DNA repair have been reported, their functions in rice (Oryza sativa) male meiosis remain poorly understood. Here, we isolated and characterized the rice OsFIGNL1 (OsFidgetin-like 1) gene, encoding a conserved AAA-ATPase, and explored its function and impo...
متن کاملPlasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.
Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the...
متن کاملPlasma Membrane Ca ATPase 4 Is Required for Sperm Motility and Male Fertility*
From the ‡Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany, the Biochemical Research and Study Center, University of Latvia, Ratsupites iela 1, Riga, LV-1067, Latvia, the **Department of Obstetrics and Gynecology, University of Wuerzburg, Josef-Schneider-Str. 2, D-97080 Wuerzburg, Germany, the ‡‡FMP, Krahme...
متن کاملThe ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair.
Cockayne syndrome (CS) is a human genetic disorder characterized by UV sensitivity, developmental abnormalities, and premature aging. Two of the genes involved, CSA and CSB, are required for transcription-coupled repair (TCR), a subpathway of nucleotide excision repair that removes certain lesions rapidly and efficiently from the transcribed strand of active genes. CS proteins have also been im...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2016
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2015.12.011